The place where you're likely to see breakage is in the Prefs for roots page.
Also, be prepared for functionality changes, because the code is fairly magical and "just works." Which means there are cases I never thought of that probably don't work.
For example, the URLs of photos in thumblist pages are wrong. They assume the photos are stored in the same place as the thumb list. This is not true when you're including a thumblist in a panel.